Meditation's Natural Pain Relief - How Does it Work?

Neuroscience of Meditation IconNeed

Meditation’s potential to reduce pain has been well established with scientific studies. However, the brain pathways by which meditation reduces pain are not well understood. 

Given how many people suffer from chronic pain, and the dangers of opioid medication abuse/addiction from traditional western pain treatment, understanding the brain chemistry by which meditation impacts pain is an important public health priority. 

Most pain relief uses the body’s natural opioid system. Opioid drugs such as morphine and fentanyl artificially active the opioid system, and mental processes such as belief or distraction can also trigger that same opioid system to naturally reduce pain. We wondered if meditation might also trigger the opioid system to naturally reduce pain.

Meditation & opioids study predicted resultsGoals

We hypothesized that meditation reduces pain by naturally triggering the opioid system. In order to test this, we used an IV drug called Naloxone that temporarily stops the opioid system from working. 

We predicted that two things could happen. 

First, when we blocked the opioid system, people’s pain could get worse. This would mean that meditation was relieving pain through the opioid system because when we turned off the opioid system, the pain relief went away. 

Or second, we thought that maybe when we blocked the opioid system, people’s pain could stay the same. This would mean that meditation was not relieving pain through the opioid system because when we turned off the opioid system, the pain relief was still there. 


We tested these predictions by recruiting people who had meditated for a long time for a laboratory study. People came in on two different days for testing. On one day, they got the IV drug Naloxone that temporarily turned off their opioid system. On the other day, they got IV saline, which is just salt water that has no impact on their pain. This study was “double-blind”, which mean that the meditator didn’t know on which day they got which drug, and also the experimenter didn’t know which day they got which drug. 

On both days we used safe equipment to give them short bursts of pain. On both days, people felt these short bursts of pain when they were just sitting in a chair like normal, and then again while they were meditating. 

ImpactMeditation & opioids study observed results

The results of this study were surprising. When we blocked the opioid system, meditation reduced people’s pain even more than normal! This is the first study to demonstrate the enhancement of pain relief via a full blockade of opioid receptors, and we’re not quite sure yet how this might be working. This provides new information not just about meditation, but about the function of the brain itself. 

But regardless how this meditation pain relief enhancement is working, temporarily turning off the opioid system didn’t make people’s pain worse. This means that meditation isn’t using the body’s opioid system to reduce pain— at least not in the normal way. 

This means that meditation could represent a promising pain-reducing intervention for people who don’t want to rely entirely (or perhaps at all) on opioids, or those with compromised natural opioid function associated with opioid use/abuse or other disorders. It’s also likely that meditation impacts other health outcomes via this same non-opioid mechanism. 

This knowledge could also be helpful for integrated pain treatment — combining meditation with other pain relief strategies that do use the opioid pathway could synergistically reduce pain. 

Before this study, we didn’t have any idea of the prevalence of mindfulness-based pain relief in long-term meditation practitioners. We know now that the vast majority of the participants in this study (85 percent) did experience pain reduction during meditation, which means it’s a common and consistent effect. 


This work was supported by a grant awarded to Lisa May from the John Templeton Foundation, which funded the Expanding the Science and Practice of Gratitude project run by UC Berkeley's Greater Good Science Center, and by a Varela award awarded to Lisa May from the Mind and Life Institute

Project Team: 
Primary Investigator
Graduate Advisor


Kosek P.
Zeidan F
, (2018)
. Enhancement of Meditation Analgesia by Opioid Antagonist in Experienced Meditators. Psychosomatic Medicine, 80(9):807-813. 10.1097/PSY.0000000000000580